Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials
Welcome to the Living Textbook of pragmatic clinical trials, a collection of knowledge from the NIH Pragmatic Trials Collaboratory. Pragmatic clinical trials present an opportunity to efficiently generate high-quality evidence to inform medical decision-making. However, these trials pose different challenges than traditional clinical trials. The Living Textbook reflects a collection of special considerations and best practices in the design, conduct, and reporting of pragmatic clinical trials.
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What is the
NIH Pragmatic Trials Collaboratory?
What is a
pragmatic clinical trial?
Training Resources
Featured
Registration Opens for Pragmatic Trials Workshop at SCT 45th Annual Meeting
The NIH Pragmatic Trials Collaboratory will offer a preconference workshop at the 45th Annual Meeting of the Society for Clinical Trials in Boston titled “Patient-Centered Research in Real-World Settings: Essentials of Embedded Pragmatic Clinical Trials.” Registration for the workshop is now open.
NIH Pragmatic Trials Collaboratory Launches New Online Training Resources
Check out the new training resources page, featuring a video library, learning modules, and workshop archives. Take a tour of the enhanced training resources webpages we built to help researchers learn about pragmatic trials.
NIH COLLABORATORY TRIALS
Pragmatic clinical trials that address questions of major public health importance and provide proof of concept for innovative pragmatic research designs.
CORES
Working groups that support the conduct of NIH Collaboratory Trials and generate guidance addressing implementation challenges.
DISTRIBUTED RESEARCH NETWORK
Network enabling investigators to collaborate in the use of electronic health data while safeguarding protected health information.
Upcoming Learning Opportunities
Grand Rounds March 29, 2024: Effect Of A Multicomponent Intervention to Improve Patient Access to Kidney Transplant and Living Kidney Donation: A Pragmatic, Cluster-Randomized Trial (Amit Garg, MD, MA, FRCPC, FACP, PhD; Stephanie N. Dixon, PhD, MSc)
March 29 @ 1:00 pm - 2:00 pmNIH Clinical Center Grand Rounds: “How Can We Respect the Dead?”
April 3 @ 12:00 pm - 1:00 pmGrand Rounds April 5, 2024: A New Look at P Values for Randomized Clinical Trials (Erik van Zwet, PhD)
April 5 @ 1:00 pm - 2:00 pmGrand Rounds April 12, 2024: Primary Palliative Care for Emergency Medicine, A Clustered-randomized Stepped-wedge Trial Across 33 Emergency Departments (Corita R. Grudzen, MD, MSHS, FACEP)
April 12 @ 1:00 pm - 2:00 pm
NEWS
- March 28, 2024: Health Equity Core Provides Reference for Equitable Language in Pragmatic TrialsThe NIH Pragmatic Trials Collaboratory’s Health Equity Core developed a written aid to offer guidance on inclusive language and terms to use when referring to specific people, groups, and communities. ...
- March 27, 2024: A Cluster Randomized Trial to Improve Kidney Transplant Access, in This Week’s PCT Grand RoundsIn this Friday’s PCT Grand Rounds, Amit Garg and Stephanie Dixon of Western University’s Schulich School of Medicine and Dentistry will present “Effect of a Multicomponent Intervention to Improve Patient Access ...
- March 25, 2024: PCORI Announces Foundational Expectations for Partnerships in ResearchThe Patient-Centered Outcomes Research Institute (PCORI) announced the release of its new Foundational Expectations for Partnerships in Research. The resource is an update of the 2014 PCORI Engagement Rubric. It ...